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51.
Xiong T Daniels J Middleton L Champaneria R Khan KS Gray R Johnson N Lichten EM Sutton C Jones KD Chen FP Vercellini P Aimi G Lui WM;International LUNA IPD Meta-analysis Collaborative Group 《BJOG : an international journal of obstetrics and gynaecology》2007,114(12):1580-e7
Background Currently, there are a number of clinical trials, but no international collaboration for collating research on effectiveness of laparoscopic uterosacral nerve ablation (LUNA) for alleviating chronic pelvic pain.
Objective Meta-analysis was used by collecting individual patient data (IPD) from the existing trials, to provide a comprehensive assessment of the effectiveness of LUNA that will be generalisable in various clinical contexts.
Methods IPD will be sought and collected from all relevant (both already finished and continuing) randomised trials identified through previous systematic reviews. After obtaining raw data and cleaning the database, analysis will be of all patients ever randomised based on the intention-to-treat principle using endpoints measured at 12 months following randomisation.
Proposal We will update searches, contact all authors, obtain data in whatever form it can be provided, build a single database, produce results for individual studies, have them verified by original authors, explore of any heterogeneity and reasons behind it and finally pool all raw data in to a meta-analysis using appropriate statistical methods. The project will test the effectiveness of LUNA for women with chronic pelvic pain. It will also motivate collaborating primary investigators to undertake new primary studies to corroborate or improve upon the conclusions derived from the retrospective analysis. 相似文献
Objective Meta-analysis was used by collecting individual patient data (IPD) from the existing trials, to provide a comprehensive assessment of the effectiveness of LUNA that will be generalisable in various clinical contexts.
Methods IPD will be sought and collected from all relevant (both already finished and continuing) randomised trials identified through previous systematic reviews. After obtaining raw data and cleaning the database, analysis will be of all patients ever randomised based on the intention-to-treat principle using endpoints measured at 12 months following randomisation.
Proposal We will update searches, contact all authors, obtain data in whatever form it can be provided, build a single database, produce results for individual studies, have them verified by original authors, explore of any heterogeneity and reasons behind it and finally pool all raw data in to a meta-analysis using appropriate statistical methods. The project will test the effectiveness of LUNA for women with chronic pelvic pain. It will also motivate collaborating primary investigators to undertake new primary studies to corroborate or improve upon the conclusions derived from the retrospective analysis. 相似文献
52.
53.
一种具有高信噪比的脉搏波光电传感器的研制 总被引:5,自引:0,他引:5
目的:探讨研制一种生理信号光电传感器。方法:利用光电传感器检测通过指端毛细血管后的光强度的变化,将光信号转换成电信号,再经过电信号1/V转换、放大、滤波处理。结果:获得了清晰稳定的指端容积脉搏波。结论:高信噪比的光电传感器可用作于临床监测和生理信号分析处理系统。 相似文献
54.
EffectofCaptoprilonAntithrombusFunctionofEndotheliumXIONGYi-li(熊一力);ZHAOHua-yue(赵华月)(DepartmentofMedicine,TongjiHospital,Tong... 相似文献
55.
56.
The concave and convex rib-vertebral angle (RVA) at levels T2–T12 was measured on AP radiographs of 19 patients with right convex idiopathic thoracic scoliosis and 10 patients with major thoracic right convex neuromuscular scoliosis. The difference between the angles on the concave and the convex sides, the RVAD, was calculated. The RVAs were also measured on radiographs from three animal groups in which spinal curves had been induced experimentally in a variety of ways. Group 1 comprised 16 rabbits that had been subjected to selective electrostimulation of the latissimus dorsi, the erector spinae and the intercostal muscles. Group 2 comprised four dead rabbits whose spines had been subjected to manual bending. Group 3 comprised eight rabbits that had undergone mechanical elongation of one rib. In both the idiopathic and the neuromuscular group, the convex RVA was smaller than the concave RVA between levels T2 and T8, with a maximal difference between T4 to T5. From T9 to T12 the concave RVA was smaller than the convex. The RVA in relation to the scoliotic segment, i.e. the apex level of the curve and the two neighbouring vertebrae above and below this level, showed similar results. With increasing Cobb angle the RVADs increased linearly with the greatest difference at the second vertebra above the apex. In the three experimental groups the pattern of the RVADs between T6 to T12 was basically similar to the findings of the clinical study. From the results of these clinical and experimental studies, it is concluded that the typical pattern of the RVAs on the concave and convex sides seems to be independent of the underlying cause of the spinal curvature. It is likely that the RVADs result from a passive mechanical adaptation of the ribs to the lateral curvature of the spine. 相似文献
57.
Summary 24 model rabbits with femoral arterial thrombosis were divided into two grocps: the treatment group consisting of 12 rabbits
which received API0134. and the control group composed of another 12 rabbits. 2 hours after recanalization by urokinase thrombolysis, reocilusion
occurred only in 1/12 vessel (8%) with incomplete occlusion in the treated group, but in 8/12 (67%) with complete occlusion
in the control group as assessed by angiograsphy. Pathological examination of specimen taken 24 hours after thrombolysis showed
that 6/12 (50%) of the treated group gave the evidence of thrombus occlusion, and milder intimai injury and less adhered blood
cells than in the control group, 83% of which had thrombus occlusion. In comparision with the control group, the function
of platelet in the treated group demonstrated lower platelet aggregation rate (PAgR) and plasma thromboxane A2 (TXA2) level, higher prostacyclin (PGI2) and plasminogen activator (PA) activity as well as lower plasminogen activator inhibitor (PAI) activity. From the above
it may be concluded that the preventive effect of API0134 on reocclusion might be due to inhibition of platelets aggregation and promotion of fibrinolysis. 相似文献
58.
健侧颈7移位治疗臂丛神经根性撕脱伤最佳时间选择的实验研究 总被引:11,自引:7,他引:4
健侧颈7移位治疗臂丛神经根性撕脱伤手术分第一阶段(健侧颈7移位到移植神经),第二阶段(移植神经另一端移植修复患侧神经),二次手术间隔多少时间才能获得最好的神经再生?选用SD大鼠及健侧颈7移位的实验模型,按二次手术间隔时间的不同(0、1、2、3、4、8、16周)分成7组,在第二次术后12周,进行电生理测定肌张力恢复率及组织切片的形态学观察,结果证实二次手术最佳间隔时间为4~8周.此结果可提供临床参考. 相似文献
59.
对原发型肺结核47例,OT 阳性、胸片阴性者9例,肺外结核6例,健康儿100例用酶联免疫吸附试验检测血清中抗人型结核菌 PPD-IgG 抗体。以大于健康儿组 OD 值(?)+2SD(即>0.23)为阳性。前三组 PPD—IgG 阳性率分别为85.1%,100.0%和100.0%。 相似文献
60.
一氧化氮合酶在肾脏缺血预处理中的表达 总被引:2,自引:1,他引:1
目的 :检测一氧化氮合酶 (NOS :eNOS ,iNOS ,nNOS)在肾脏缺血预处理动物模型肾组织中的表达 ,探讨NOS在肾脏缺血预处理中的可能作用机制。方法 :将 36只小白兔随机分为四组即对照组、缺血预处理组(IP)、缺血再灌注组 (I/R)和缺血预处理后再灌注组 (IP +I/R)。分别检测各组肾组织中NOS的表达及组织学变化。结果 :在急性肾缺血 6 0min再灌注 6 0min时 ,eNOS阳性表达在IP组和IP +I/R组明显高于I/R组和对照组 (P <0 .0 1) ,iNOS和nNOS在组织肾中未见明显表达。组织学变化发现I/R组肾组织中肾细胞发生明显变性坏死 ,而IP组和对照组未见明显改变。结论 :肾脏缺血预处理在肾脏缺血再灌注中具有保护作用 ,而NOS参与该作用机制。 相似文献